Web1 Nov 2024 · The present study aimed to elucidate the role of transcription factor EB (TFEB), a master regulator of autophagy, in mediating adipoRon's effect on SMCs. In cultured … WebDamage-Regulated Autophagy Modulator 1 (DRAM1) is an infection-inducible membrane protein, whose function in the immune response is incompletely understood. Based on previous results in a zebrafish infection model, we have proposed that DRAM1 is a
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Web10 Apr 2024 · In this issue of JCB, Jiménez-Moreno et al. used siRNA and shRNA knockdown and CRISPR/CAS9-mediated knockout of LMX1B in cells combined with rescue experiments with WT and mutants to confirm that LMX1B is indeed a transcriptional regulator of a number of autophagy genes. To address the knowledge gap on the role of … Web23 Apr 2015 · In contrast, expression of TFEB shRNA prevented the potentiation of cell death by RIP1 depletion in response to FasL (Fig 5G). Finally, pharmacological inhibition … ウエイトコントロール 意味
Ruth M Alvarez University of Southern California 2 Publications ...
WebTFE3 and TFEB have also been reported to regulate some autophagy-related genes [26,27]. Thus, the LC3-II, ... We further examined OSW-1-induced cell death since the knockdown of OSBP in HeLa cells using shRNA significantly increased OSW-1 sensitivity . However, the effect of OSBP deficiency was observed only to a small extent in this study ... WebTFEB knockdown with either shRNA led to an increase in HIF-1α protein levels (Fig. 4I) and HIF-1 reporter activity (Fig. 4J). FIGURE 4 TFEB decreases HIF-1α levels and HIF-1 activity. A , HeLa cells were transfected with empty vector ( EV ) or TFEB expression vector. 24 h post-transfection, RNA was isolated, and RT-qPCR was performed. Web12 Jul 2024 · To understand better the functions of TFEB in TSC, we knocked down Tfeb in Tsc2 -expressing and deficient MEFs with two different shRNAs (Fig. 4a ). Downregulation of Tfeb decreased the... pagopa ministero dell\u0027istruzione