Web24 Feb 2024 · t 1/2 (elimination half-life) is the time required to decrease the concentration of a drug within the body by one-half during elimination. 2. The t max is dependent on the absorption rate constant (ka) and elimination rate (k). t 1/2 is dependent on the volume of distribution (Vd) and elimination rate (k). 3. At t max, the drug concentration is ... Web30 May 2024 · The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. Half-life is used to estimate how long it takes for a drug …
Elimination half-life of drugs: value and limitations - PubMed
WebAprotinin elimination is biphasic, with an initial plasma half-life of 0.7 hours and a terminal phase plasma half-life of approximately 7 hours. Its primary route of elimination is the … WebIn fact, elimination half-life has limitations, and its value has been overestimated. Elimination half-life is a dependent variable, related directly to volume of distribution and inversely to clearance. Changes in drug distribution as well as in rate of clearance can alter elimination half-life. hoover cordless air bh50111
terminal half-life - English definition, grammar, pronunciation ...
Web3 Jun 2009 · Answer: The half life is the time it takes for the plasma concentration or the amount of drug in the body to be reduced by 50%. In the simplest model of drug … WebIn fact, elimination half-life has limitations, and its value has been overestimated. Elimination half-life is a dependent variable, related directly to volume of distribution and … Webnoun. The biological half-life or terminal half-life of a substance is the time it takes for a substance (for example a metabolite, drug, signalling molecule, radioactive nuclide, or other substance) to lose half of its pharmacologic, physiologic, or radiologic activity. Drinking large amounts of alcohol will reduce the biological half-life of ... hoover cordless backpack parts