Webb21 apr. 2024 · In this study, passive Heymann nephritis (PHN) model was used to observe the therapeutic effect of MFSD on MN rodent model, and a deliberate strategy integrating network pharmacology and pharmacodynamics methods was employed to investigate the potential target of MFSD for the MN treatment. Materials and Methods Animals and … WebbThe pathological basis of FSGS and MCD appears to essentially be podocyte-related, as evidenced by podocyte foot processes effacement, microvillus transformation, and podocytopenia. 23 Knockout and transgenic models have provided proof of concept that mutations in specific podocyte proteins mediate genetic forms of FSGS. 24 A study was …
Triptolide reduces proteinuria in experimental ... - Kidney …
Webb29 mars 2024 · To test pyroptosis in vivo, we used the PHN rat model to verify the expression of pyroptosis-related molecules. The increase in urinary protein levels (Fig. (Fig.6A) 6A ) and characteristic morphology of MN, such as the subepithelial electron-dense deposits under the electron microscope (Fig. (Fig.6B), 6B ), indicated that the PHN … Webb3 aug. 2024 · Twelve PHN rat models were established by intraperitoneal injection of resiniferatoxin, with an additional 12 rats serving as controls. Nociceptive behavioral tests were performed on these rats and fMRI scans were performed on days 7 and 14 after modeling. Functional connection (FC) analysis was used to investigate the brain FC … software engineering projects for resume
Resting-State Functional Connectivity Analyses: Brain Functional ...
Webb3 aug. 2024 · Twelve PHN rat models were established by intraperitoneal injection of resiniferatoxin, with an additional 12 rats serving as controls. Nociceptive behavioral tests were performed on these... WebbInvestigation of the neural mechanisms underlying PHN has been facilitated by the introduction of an in vivo rat model of varicella zoster virus (VZV) persistent infection … Webb30 jan. 2014 · PHN in rats and adriamycin-induced nephropathy in mice are well-characterized models resembling human MN and FSGS respectively. PHN is characterized by immune deposits formed in situ in the glomerulus, triggered by antigen expression on the podocyte surface [14], mainly megalin [2]. slower charger