Ginkgolic acid genotoxicity

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August undefined, 2024

WebDec 22, 2014 · A series of standard solutions of ginkgolic acid 13:0 in the range of 2 to 50 mg/L were analyzed with a correlation coefficient r = 0.9981 and relative standard … WebSep 6, 2012 · Ginkgo biloba has long been used in traditional Chinese medicine. In this study, ginkgoneolic acid, a kind of compound extracted from G. biloba, was investigated …

Cytotoxicity of ginkgolic acid in HepG2 cells and primary rat ...

WebGinkgolic acid. Allergy: Allergic contact dermatitis has been reported particularly to the fruit and nuts of female trees. Food poisoning has occured in Japan when too many nuts are eaten:. It appears to be caused by … WebAug 1, 2024 · Antitumor effects of ginkgolic acid in human cancer cell occur via cell cycle arrest and decrease the Bcl-2/Bax ratio to induce apoptosis. ... Review of current and … s ptf

Ginkgolic Acid (15:1) - Sigma-Aldrich

WebJan 2, 2015 · Ginkgolic acids (GAs) are alkylphenols which can be found in the fruits and leaves of Ginkgo biloba L. (Ginkgoaceae) used in herbal teas, drugs and food … WebJun 12, 2024 · Ginkgolic acid C15:1 (1) and ginkgolic acid C15:0 (2) are natural acids isolated from Ginkgo biloba . 1 Ginkgolic acid is a component of a botanical extract which shows pleiotropic effects including antitumor and anti-HIV activities. 2 The synthesis of (1) has been reported by Martin in 2024 using a Heck-based strategy. 3 Several ... WebApr 24, 2024 · That is because — as co-first author François Chassagne, Ph.D., explains — concentrated ginkgolic acid C15:1 is actually toxic to the skin itself. Huang herself notes that, even when she ate ... spt facebook

Characterization of Alkylphenol Components in

Ginkgo biloba , DNA Damage and DNA Repair: Overview

Web1) Safety: Watch Out for Ginkolic Acid! Most people aren’t aware that Ginkgo leaves contain a toxic compound, ginkgolic acid. Pharmaceutical-grade Ginkgo extract must contain … WebExamples of such compounds include terpene trilactones (ginkgolides), acylated flavonol glycosides (ginkgoghrelins), biflavones (ginkgetin), ginkgotides and ginkgolic acids. The extract of G. biloba leaf is used to prevent and/or treat cardiovascular diseases, while many ginkgo-derived compounds are currently at various stages of preclinical ... spt evaporative air cooler reviewWebAug 17, 2024 · Ginkgo biloba leaf extract (EGb) is high in bioactive components (over 170), which are used in food additives, medicine, cosmetics, health products, and other sectors. Nonetheless, ginkgolic acids (GAs) in Ginkgo biloba (GB) have been identified as the primary source of EGb's adverse effects such as embryotoxicity, cytotoxicity, … spt exchange cpt

"WebDec 22, 2014 · A series of standard solutions of ginkgolic acid 13:0 in the range of 2 to 50 mg/L were analyzed with a correlation coefficient r = 0.9981 and relative standard deviation (n = 5) from 12.5 to 13.7 ... " - Ginkgolic acid genotoxicity

Ginkgolic acid genotoxicity

Structure, synthesis, biosynthesis, and activity of the …

WebMay 28, 2024 · Ginkgolic acid inhibits HIV protease activity and HIV infection in vitro. Lu. Med. Sci. Monit., Br293- 2012 Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate. Fukuda I, Ito A, Hirai G, Nishimura S, Kawasaki H, Saitoh H, Kimura K, Sodeoka M, Yoshida M. Chem Biol, (2):133-140 2009 ...

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WebJan 5, 2024 · Genotoxicity of GBE includes induction of DNA double-strand breaks by a prooxidant mechanism, associated to activation of DNA damage signaling pathways, and inhibition of topoisomerase II. ... GBE inhibits SUMOylation, in which ginkgolic acid seems to be main active component as a result of its direct interaction with SUMO-activating … WebAug 1, 2024 · Schematic process for removing ginkgolic acid using (A) salicylic acid decarboxylase, 48 (B) immobilized-laccase, in which core/shell composite nanoparticles …

WebJul 1, 2009 · The overall five individual common components in ginkgolic acids, namely 13:0 ginkgolic acid, 15:0 ginkgolic acid, 15:1 ginkgolic acid, 17:1 ginkgolic acid, and 17:2 ginkgolic acid are determined. ... WebJan 2, 2024 · The genotoxicity of a Ginkgo biloba leaf extract (obtained from Shanghai Xing Ling Science and Technology Pharmaceutical Co., Shanghai, ... The embryotoxic effects of ginkgolic acid were confirmed by comparing the LD50 values in fresh fertile …

WebOct 26, 2016 · Ginkgo leaf is the most used form of supplement for cognitive ailments. The standardized extract formulation EGb 761 is a dietary supplement with proven benefit in several neurological and psychiatric conditions including memory decline in Alzheimer’s disease, schizophrenia and dementia. Ginkgolic acid (GA) is a component of this … WebMar 3, 2024 · Based on the quantitative data, the concentrat ion of ginkgolic acid C15:1 and C1 7: 1 in 60 % . ethanolic extracts of ginkgo leaves was signi cantly greater than the acceptable lev el of 5 .

WebMar 1, 2012 · A method to determine alkylphenols in Ginkgo biloba sarcotesta, especially focusing on polyunsaturated ginkgolic acid components, was developed on the basis of thermochemolysis–gas …

WebJan 1, 2024 · Genotoxicity refers to the potential for an agent to cause DNA lesions that can result in cell death, or mutations which can lead to cancer, and is an important category in hazard identification studies. ... kaempferol, quercetin, and isorhamnetin), biflavones, proanthocyanidins, alkylphenols (i.e., ginkgolic acid), simple phenolic acids, 6 ... sptf caderousseWebDec 26, 2024 · Results. Our data showed that the proliferation inhibition rate of cells at each ginkgolic acid concentration was higher than that of the control group (P < 0.05), suggesting that GA has an inhibitory influence on the proliferation of OCa cells, in a dose-dependent way.GA was able to inhibit the proliferation rate and migration ability of OCa … sptf conectoresWebAug 1, 2024 · Schematic process for removing ginkgolic acid using (A) salicylic acid decarboxylase, 48 (B) immobilized-laccase, in which core/shell composite nanoparticles were generated by coaxial ... sptf armyWebTo further assess the adverse properties of alkylphenols, different fractions derived from the decanter sludge were evaluated for their embryotoxic effects in the hen's egg test (HET). A fraction enriched for ginkgolic acids (16%) and biflavones (6.7%) was found to induce death of 50% of the chick embryos (LD50) at a dose of 1.8 mg/egg ... sptf ceriseWebNational Center for Biotechnology Information. 8600 Rockville Pike, Bethesda, MD, 20894 USA. Contact. Policies. FOIA. HHS Vulnerability Disclosure. National Library of … sptf facebookWebOct 29, 2015 · Ginkgolic acid in nanomolar concentrations causes potentiation of I gly mediated by homomeric α1 GlyRs expressed in CHO cells. (A) Structure of ginkgolic acids from G.biloba used in this study.(B) Whole-cell currents induced by 30 μM glycine in control (black trace) and at the different time points of treatment of cells with 30 nM of ginkgolic … spt familyWebFeb 28, 2024 · In the urgent campaign to develop therapeutics against SARS-CoV-2, natural products have been an important source of new lead compounds. We herein identified two natural products, ginkgolic acid and anacardic acid, as inhibitors using a high-throughput screen targeting the SARS-CoV-2 papain-like protease (PLpro). Moreover, our study … spt failed to find matching source file