Citrate transporter family protein

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August undefined, 2024

WebNational Center for Biotechnology Information WebThis gene encodes a sodium-driven citrate transport protein named NaCT. Disease-causing mutations abolish the uptake of citrate in neurons of the brain. ... (NaDC) from the SLC13 family. A number of mutations have been identified in the NaCT transporter gene (SLC13A5) in patients with epileptic encephalography. The Pajor Lab explores what …

Tricarboxylate transport protein, mitochondrial - Wikipedia

WebSLC13A5. Solute carrier family 13 (sodium-dependent citrate transporter), member 5 also known as the Na+/citrate cotransporter or mIndy is a protein that in humans is encoded by the SLC13A5 gene. [5] It is the mammalian homolog of the fly Indy gene . WebTricarboxylate transport protein, mitochondrial, also known as tricarboxylate carrier protein and citrate transport protein (CTP), is a protein that in humans is encoded by … chiropractor stony point

Molecular Mechanism of Citrate Efflux by the …

WebThis gene encodes a member of the mitochondrial carrier subfamily of solute carrier proteins. Members of this family include nuclear-encoded transporters that translocate … WebMar 1, 2024 · The Mitochondrial Carrier Family. With 53 members, the mitochondrial carrier family (solute carrier family 25, SLC25) is the largest solute transporter family in humans. They transport solutes across the impermeable inner membrane of mitochondria for important cellular processes, such as oxidative phosphorylation of fats and sugars, … WebFeb 12, 2024 · As the prototype for the TTT family, the TctC citrate transporter was first described by Sweet et al. (1979) in the pathogen Salmonella typhimurium, one of the most important causative agents of food-borne gastrointestinal infections and a growing problem due to the recent emergence of multidrug resistant strains (Hur et al., 2012). graphic tees hm

Citrate transport and metabolism in mammalian cells: prostate ...

WebMar 11, 2016 · Multidrug and toxic compound extrusion (MATE) family is the most recent categorized multidrug efflux transporter family, which is a secondary transporter family that couples the translocation of substrates with an electrochemical gradient of cations (such as H + or Na + ions) across the membrane [1, 2].The X-ray structure of the MATE … WebAn insertion in the rice citrate efflux transporter gene OsFRDL4 increased its promoter activity and improved its expression, thereby enhancing Al tolerance ... The PHT family protein PHT5 in the vacuolar membrane regulates cytoplasmic Pi homeostasis to enhance plant growth under Pi deficiency (Lin et al. 2024; ... graphic tees ideaWebLiver cells import citrate through the sodium-dependent citrate transporter NaCT (encoded by SLC13A5) and, as a consequence, this protein is a potential target for anti-obesity drugs. Here, to understand the structural basis of its inhibition mechanism, we determined cryo-electron microscopy structures of human NaCT in complexes with citrate or ... chiropractor study

"WebDec 15, 2024 · Iacobazzi et al. (1997) determined that the open reading frame of the human citrate transporter gene encodes a mature protein of 298 amino acids and a … " - Citrate transporter family protein

Citrate transporter family protein

Structure and inhibition mechanism of the human citrate …

WebNov 14, 2008 · Recently, three studies have reported that some MATE proteins are involved in the transport of citrate, which is required for iron (Fe) translocation or … WebMay 14, 2024 · To study the citrate transport mechanism of CT, the citrate transporter gene was expressed in Escherichia coli, and its product was purified. The citrate …

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WebFeb 11, 2002 · Citrate transport protein (CTP) Mitochondrial citrate carrier 1 publication (CIC 1 publication) Solute carrier family 25 member 1; Tricarboxylate carrier protein; … WebOct 10, 2013 · The SLC13 family in humans and other mammals consists of sodium-coupled transporters for anionic substrates: three transporters for dicarboxylates/citrate and two transporters for sulfate. This review will focus on the di- and tricarboxylate transporters: NaDC1 (SLC13A2), NaDC3 (SLC13A3), and NaCT (SLC13A5). The substrates of these …

WebCitrate transporter family protein Imported. Gene names. Ordered locus names. PFL_2499 Imported. Organism names. Organism. Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) Imported. Taxonomic … WebApr 7, 2024 · The TaALMT1 gene has been found to belong to a new transporter family and regulates the selective efflux of malate. ... and sorghum [48], and its homologue were then identified as OsFRDL4 (a MATE family citrate transporter) in rice [49 ... (OsSTAR1/2, encodes an ABC transporter protein that forms a complex to regulate the efflux of UDP …

Webet al., 2004). Functional gene variants of transport proteins are involved in human diseases, and about 10% of established T2D loci are related to membrane transporters. II. Solute Carrier Membrane Transport Proteins Solute carrier (SLC) proteins are a group of trans-membrane transporters that mediate solute influx WebCitrate plays a pivotal role not only in the generation of metabolic energy but also in the synthesis of fatty acids, isoprenoids, and cholesterol in mammalian cells. Plasma levels …

WebJan 20, 2024 · Moreover, mutations of a member of the citrate transporter family in fruit fly, INDY, promote longevity, ... Inhibitors of the mitochondrial citrate transport protein: validation of the role of ...

WebFeb 23, 2024 · The small molecule citrate is a key molecule that is synthesized de novo and involved in diverse biochemical pathways influencing cell metabolism and function. Citrate is highly abundant in the circulation, and cells take up extracellular citrate via the sodium-dependent plasma membrane transporter NaCT encoded by the SLC13A5 gene. … chiropractor study requirementsWebMay 14, 2024 · The citrate transport activity of the protein was studied in CT reconstituted liposomes. Our results showed high efficiency of CT for [ 14 C] citrate/citrate exchange with K m 0.01 mM at 25°C. graphic tee sims 4 ccWebJul 1, 2007 · The cellular transport of long-chain fatty acids (LCFAs) across the plasma membrane has long been thought to occur via passive diffusion. However, in recent years a substantial body of literature has emerged indicating that LCFA uptake into muscle cells occurs via a protein-mediated process (for review see Bonen et al. 2002; Luiken et al. … graphic tees indieWebThe partially compromised nodule functioning induces two striking phenotypes: anthocyanin accumulation already displayed 4 weeks after inoculation and shoot biomass deficiency, which is detected by long-term phenotyping. LjNPF8.6 achieves nitrate uptake in Xenopus laevis oocytes at both 0.5 and 30 mm external concentrations, and a possible role ... chiropractor sudburyWebsolute carrier family 20 (mitochondrial citrate transporter), member 3; solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1; ... Iacobazzi V, Lauria G, … chiropractors \u0026 chiropractic treatmentWebMar 21, 2024 · This gene encodes a protein belonging to the solute carrier family 13 group of proteins. This family member is a sodium-dependent citrate cotransporter that may … graphic tee shirts menWebFeb 17, 2024 · Liver cells import citrate through the sodium-dependent citrate transporter NaCT (encoded by SLC13A5) and, as a consequence, this protein is a potential target for anti-obesity drugs. chiropractor study nz